Local and systemic immune responses to rectal administration of recombinant cholera toxin B subunit in humans

Authors
Jertborn, M Nordstrom, I Kilander, A Czerkinsky, C Holmgren, J
Citation
M. Jertborn et al., Local and systemic immune responses to rectal administration of recombinant cholera toxin B subunit in humans, INFEC IMMUN, 69(6), 2001, pp. 4125-4128
Citations number
24
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
6
Year of publication
2001
Pages
4125 - 4128
Database
ISI
SICI code
0019-9567(200106)69:6<4125:LASIRT>2.0.ZU;2-Z
Abstract
The induction of immune responses to rectally administered recombinant chol era toxin B subunit (CTB) in humans was studied. Three immunizations induce d high levels of CTB-specific antibody-secreting cells, particular of the i mmunoglobulin A isotype, in both rectum and peripheral blood. Antitoxin ant ibody responses in rectal secretions and serum were also found.