gp96-peptide vaccination of mice against intracellular bacteria

This work demonstrates that gp96 preparations isolated from cells infected with intracellular bacteria induce cytotoxic T-lymphocyte responses and con fer protection. Our findings extend previous reports on the immunogenicity of gp96-associated peptides to antigens derived from intracellular bacteria . Immunization with gp96 may therefore represent a promising vaccination st rategy against bacterial pathogens.