Priming by DNA immunization augments protective efficacy of Mycobacterium bovis bacille Calmette-Guerin against tuberculosis

Authors
Feng, CG Palendira, U Demangel, C Spratt, JM Malin, AS Britton, WJ
Citation
Cg. Feng et al., Priming by DNA immunization augments protective efficacy of Mycobacterium bovis bacille Calmette-Guerin against tuberculosis, INFEC IMMUN, 69(6), 2001, pp. 4174-4176
Citations number
20
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
69
Issue
6
Year of publication
2001
Pages
4174 - 4176
Database
ISI
SICI code
0019-9567(200106)69:6<4174:PBDIAP>2.0.ZU;2-L
Abstract
Sequential immunization with mycobacterial antigen Ag85B-expressing DNA and Mycobacterium bovis bacille Calmette-Guerin (BCG) was more effective than BCG immunization in protecting against Mycobacterium tuberculosis infection . Depletion of the CD8(+) T cells in the immunized mice impaired protection in their spleens, indicating that this improved efficacy was partially med iated by CD8(+) T cells.