We have studied cytosolic low molecular weight phosphotyrosine phosphatase
(cLMWPTP or ACP1) in 364 healthy puerperae from the population of Penne, in
155 diabetic puerperae from the population of Rome and in 349 consecutive
normal newborn infants from the population of Rome. The data from these ind
ependent samples point to a protective role of maternal ACP1 genotypes with
medium-high activity against intrauterine growth retardation caused by smo
king.