L. Zarantonelli et al., Decreased susceptibility to azithromycin and erythromycin mediated by a novel mtr(R) promoter mutation in Neisseria gonorrhoeae, J ANTIMICRO, 47(5), 2001, pp. 651-654
During a screen of Neisseria gonorrhoeae clinical isolates obtained in Urug
uay for susceptibility to azithromycin, we noticed that approximately 10% o
f the strains examined displayed decreased susceptibility to azithromycin a
nd erythromycin due to the mtr(CDE)-encoded afflux pump system, but remaine
d susceptible to Triton X-100, We now report that the mtr(R) promoter regio
n of one of these isolates contains a dinucleotide insertion (TT) that medi
ates this resistance phenotype.