Effect of LY333328 against vancomycin-resistant Enterococcus faecium in a rat central venous catheter-associated infection model

A rat central venous catheter (CVC) infection model was used to assess the activity of LY333328 against vancomycin-resistant Enterococcus faecium (VRE ), Via the CVC, animals were challenged with 10(6) cfu of Enterococcus faec ium with the VanA phenotype, Eight rats received a single dose of LY333328 and eight rats received saline, Seventy-five per cent of control animals ha d peripheral bacteraemia and 87.5% had VRE recovered from explanted CVCs at the time they were killed, as compared with 0 and 12.5%, respectively, of the LY333328-treated animals (P < 0.01), All animals in the control group h ad evidence of metastatic disease compared with none of the treated group ( P < 0.01), LY333328 was effective against the strain of VRE tested in this model.