Pancreatic concentrations of cefepime

The concentrations of cefepime in pancreatic pseudocyst fluid (n = 4), panc reatic tissue (n = 4) and pancreatic fistula fluid (n = 1), and simultaneou s plasma concentrations, were measured after intravenous administration of a single 2 g dose to nine patients. Mean plasma concentration was 27.4 mg/L between 120 and 200 min after the end of infusion. Mean pancreatic cefepim e concentration was 6.3 mg/L in pseudocyst and 10.7 mg/L in pancreatic tiss ue. Cefepime was detected by 30 min after the end of the perfusion in pancr eatic fistulae fluid, and persisted at 8 h, We conclude that cefepime is a potentially useful antibiotic in prevention and treatment of pancreatic inf ection.