Pulsed photothermal radiometry as a method for investigating blood vessel-like structures

Pulsed photothermal radiometry (PPTR) is known to be suitable for in vivo i nvestigations of tissue optical properties. As a noncontact, nondestructive method it is a very attractive candidate for on-line dosimetry of laser tr eatments that rely on thermal laser-tissue interaction. in this article, we extend the one-dimensional (1D) analytical formalism that has widely been used to describe PPTR signals to a two-dimensional treatment of a simplifie d model of a blood vessel. This approach leads to quantitative description of a PPTR signal that, unlike in an 1D treatment, not only shows changes in time, but also varies in space. Using this approach, we are able to gain i nstructive understanding on how target characteristics of a blood vessel-li ke structure influence such a spatiotemporal PPTR signal. Likewise, the abi lity of extracting target features from those measurements is evaluated. Su bsequently, we present experimental realization of the idealized model of a blood vessel as used in our theory. Comparison of actual PPTR measurements with theoretical predictions allow vessel localization laterally and in de pth. Using our setup, we furthermore demonstrate the influence of flow insi de the vessel on the measured signal. (C) 2001 Society of Photo-Optical ins trumentation Engineers.