Dose selection and comparator drugs in schizophrenia research

Dose selection and comparator drugs are important methodological issues in the evaluation of clinical data. Investigators rely heavily on dose selecti on in schizophrenia research, particularly when making comparisons between and across groups of compounds. In reality, however, the criteria for selec ting a dose of drug in research trials are rather crude. Dosing and compara tor issues vary enormously, depending on several factors. This article will discuss some of the dose-selection issues in schizophrenia research and th e doses of antipsychotic drugs used in 5 recent comparative clinical trials .