Enhancing effect of electret on transdermal drug delivery

The present work was undertaken to study the enhancing effect of electret o n in vitro transdermal drug delivery. The experiment was conducted using th e improved Franz diffusion cells, with the skin of rat mounted between the two half cells and the electret film covered on the model compound in the d onor cell. The receiver solution was withdrawn at a predetermined time and the concentration was measured by high performance liquid chromatography (H PLC). The results showed that the penetration flux of methyl salicylate in the electret group was 1.55 times greater than that in the control group. T his indicated that the microcurrent and static field that the electret prod uced could influence the drug permeation through the skin. (C) 2001 Publish ed by Elsevier Science B.V.