Heart rate-lowering calcium antagonists in hypertensive post-myocardial infarction patients

Objectives To analyse effects of a heart rate-lowering calcium antagonist i n hypertensive post-myocardial infarction patients. Design and methods From three large, randomized, placebo-controlled, second ary prevention trials investigating verapamil or diltiazem (the first and s econd Danish Verapamil Infarction Trials and the Multicentre Diltiazem Post -Infarction Trial) data from a total of 1325 hypertensive post-myocardial i nfarction patients (drugs = 667, placebo = 658) were pooled to assess effec t of blinded therapy on mortality and event rates. Results Treatment with heart rate-lowering calcium antagonists was associat ed with significant reduction in event rates [21.4 versus 27.4%; risk ratio (RR)= 0.76, confidence interval (CI)= 0.61-0.95, P = 0.013], Mortality rat es in the treatment group were 15.1 versus 17.5% in the control group (RR = 0.87, CI = 0.66-1.13, P = 0.296). Among the subset of 964 hypertensive pat ients without pulmonary congestion, there was some reduction in mortality r ate (11.3 versus 15.3% in the control group; RR = 0.72, P = 0.066) and sign ificant reduction in event rates (18 versus 24.4% for control group; RR = 0 .70, P = 0.011). In patients with pulmonary congestion and hypertension, ho wever, calcium antagonists were associated with a 25% increase in mortality (RR = 1.25, P = 0.339), while event rate RR was 1.00. After an adjustment for significant covariates, RR for mortality in treatment versus control gr oups was 0.76 (P = 0.159). For event rates, RR was 0.74 (P = 0.057). Conclusions Heart rate-lowering calcium antagonists decrease event rates in hypertensive post-myocardial infarction patients, but only in those withou t pulmonary congestion. J Hypertens 19:977-982 (C) 2001 Lippincott Williams & Wilkins.