Effectiveness of mitomycin C in reducing reformation of adhesions following surgery for restrictive strabismus

Purpose: To evaluate the efficacy of mitomycin C in reducing reformation of adhesions following surgery for restrictive strabismus. Methods: Sixteen patients with restrictive strabismus resulting from trauma , retinal detachment surgery, and multiple squint surgeries were randomized to either a mitomycin group (8 patients) or a control group (8 patients). Mitomycin C (0.2 mg/mL) was applied intraoperatively for 5 minutes after re lease of adhesions. Range of passive ductions was scored for comparison. Po stoperative follow-up ranged from 3-18 months. Results: Compared to controls, the mitomycin C group had better range of pa ssive ductions. There were no com plications related to the cornea, intraoc ular pressure, uveitis, or muscle disinsertion in the mitomycin C group. Conclusion: Intraoperative application of mitomycin C (0.2 mg/mL for 5 minu tes) is a safe and effective adjunct to surgery in the treatment of restric tive strabismus.