Scientific studies have been conducted to quantify attributes that may be i
mportant in the creation of more functional and comfortable lower-limb pros
theses. The prosthesis socket, a human-machine interface, has to be designe
d properly to achieve satisfactory load transmission, stability, and effici
ent control for mobility. The biomechanical understanding of the interactio
n between prosthetic socket and the residual limb is fundamental to such go
als. The purpose of this paper is to review the recent research literature
on socket biomechanics, including socket pressure measurement, friction-rel
ated phenomena and associated properties, computational modeling, and limb
tissue responses to external mechanical loads and other physical conditions
at the interface. There is no doubt that improved biomechanical understand
ing has advanced the science of socket fitting. However, the most recent ad
vances in the understanding of stresses experienced at the residual limb ha
ve not yet led to enough clinical consensus that could fundamentally alter
clinical practice. Efforts should be made to systematically identify the ma
jor discrepancies. Further research should be directed to address the criti
cal controversies and the associated technical challenges. Developments sho
uld be guided to offer clinicians the quantification and visualization of t
he interaction between the residual limb and the prosthetic socket. An unde
rstanding of comfort and optimal load transfer as patterns of socket interf
ace stress could culminate in socket design expert systems.