Many patients with upper limb intention tremor encounter difficulties in mo
use-driven interaction with the personal computer (PC). An assistive techno
logy system ("the Tremor Control System"), consisting of a motion-filtering
software program that supports multiple interfaces, was developed and vali
dated with 36 persons with Multiple Sclerosis in a multi-center trial. PC-t
ests, requiring basic functions such as cursor placement and click and drag
function, were able to differentiate between patients and control subjects
(ANOVA: p<0.05). A significant time improvement on the PC-tests was found
when using an optimal alternative interface instead of the standard PC-mous
e (paired t-tests: p<0.01 for Point & Click test, p<0.05 for Drag & Drop te
st and p<less than>0.1 for Double Click test). A significant time improveme
nt was found for the Double Click test (paired t-tests: p<0.05) when the mo
tion-filtering program was implemented. The number of patients able to perf
orm fully the PC-tests increased with the Tremor Control System. Patients w
ith marked intention tremor seemed to profit especially from this assistive
technology. These users reported that working with the Tremor Control Syst
em was less fatiguing and more comfortable compared to the use of the stand
ard PC-mouse.