Two-generation reproductive toxicity study of tributyltin chloride in female rats

Citation
R. Ogata et al., Two-generation reproductive toxicity study of tributyltin chloride in female rats, J TOX E H A, 63(2), 2001, pp. 127-144
Citations number
48
Categorie Soggetti
Environment/Ecology,"Pharmacology & Toxicology
Journal title
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
ISSN journal
15287394 → ACNP
Volume
63
Issue
2
Year of publication
2001
Pages
127 - 144
Database
ISI
SICI code
1528-7394(20010525)63:2<127:TRTSOT>2.0.ZU;2-4
Abstract
A two-generation reproductive toxicity study of the effects of tributyltin chloride (TBTCl) was conducted in female rats using dietary concentrations of 5, 25, and 125 ppm TRTCl. Reproductive outcomes of darns (number and bod y weight of pups and the percentage or live pups) and the growth of female pups (the day of eye opening and body weight gain) were significantly decre ased in the 125 ppm TBTCl group. A delay in vaginal opening and impaired es trous cyclicity were also observed in the 125 ppm TBTCl group. However, an increase in anogenital distance was found in all TBTCl groups on postnatal d 1. A dose-effect relationship was observed in TBTCl-induced changes in an ogenital distance. These results indicate that the whole-life exposure to T BTCl affects the sexual development and reproductive function of female rat s. In addition, the TBTCl-induced increase in anogenital distance seems to suggest it may exert a masculinizing effect on female neonates. However, th e concentrations of TBTCl used in this study are not environmentally releva nt.