Expression of frizzled genes in mouse costochondral chondrocytes

Protein products of frizzled genes are cell membrane receptors for Wnt prot eins that play multiple roles during development. We examined the expressio n of nine frizzled genes in mouse chondrocytes, and detected transcripts of six of the nine genes. We also cloned the entire cDNA of mouse frizzled-l and compared its cDNA sequence and the cysteine-rich and transmembrane doma ins of its translated product to sequences of frizzled-l from C. elegans, D rosophila, chicken and human. We used the T31 Mouse/Hamster radiation hybri d panel to map the mouse frizzled-l to mouse chromosome 5 (5 cM from the ce ntromere), and frizzled-9 to mouse chromosome 5 (74 cM from the centromere) . (C) 2001 Elsevier Science B.V./International Society of Matrix Biology. A ll rights reserved.