RECURRENCE OF HODGKINS-DISEASE AFTER 10 OR MORE YEARS - LATE RELAPSE OR DE-NOVO MALIGNANCY DUE TO HLA-DPB1-ASTERISK-0301-LINKED SUSCEPTIBILITY

Recurrences of Hodgkin's disease (HD) ten or more years after initial therapy are rare and heterogeneous concerning pathological, biological and clinical features. Though usually regarded as relapses of initial disease at least part of these late recurrences may represent de-novo HD due to an increased constitutional risk. Following recent reports genetic risk for HD may be linked to the HLA-DPB10301 allele. Therefo re, we investigated DPB1 and other HLA class I and II gene loci in thr ee patients with very late recurrences of HD presenting at our institu tion within the last two years. All patients carry the HD susceptibili ty allele HLA-DPB10301. The expected probability of three patients wi th HD displaying the HLA-DPB10301 phenotype by chance is only p = 0.0 22. As serologic investigations also revealed Epstein-Barr virus (EBV) activity in all three cases our results support a role of genetic sus ceptibility possibly leading to impaired immune responses to EBV in ve ry late recurring HD. Additionally, HLA-DPB10301 may be valuable for identifying patients with HD who might be candidates for a long termfo llow-up.