The effect of resveratrol on the platelet secretory process induced by endotoxin and thrombin

The effect of resveratrol (trans-3,4',5-trihydroxystilbene) on the release of adenine nucleotides and proteins from blood platelets activated by lipop olysaccharide (FPS), from Proteus mirabilis and by thrombin, were studied. Thrombin stimulated the release of adenine nucleotides from dense granules and proteins from or-granules. The LPS (0.3 mug/10(8) platelets, 5 min, 37 degreesC), like thrombin (2.5 U/10(8) platelets. 5 min, 37 degreesC) was fo und to cause a release of adenine nucleotides and proteins (p <0.05). Resve ratrol (6.25-100 mug/ml, 30 min. 37 degreesC) had a different effect on the platelet release reaction caused by either LPS or thrombin. The results in dicated that resveratrol inhibited, in dose-dependent manner, the secretory process (release of adenine nucleotides and proteins) induced by thrombin (p <0.05), but it significantly stimulated the liberation of proteins from blood platelets activated by LPS (p <less than>0.05).