Reduced skeletal muscle calpain-10 transcript level is due to a cumulativedecrease in major isoforms

Authors
Yang, XL Pratley, RE Baier, LJ Horikawa, Y Bell, GI Bogardus, C Permana, PA
Citation
Xl. Yang et al., Reduced skeletal muscle calpain-10 transcript level is due to a cumulativedecrease in major isoforms, MOL GEN MET, 73(1), 2001, pp. 111-113
Citations number
7
Categorie Soggetti
Molecular Biology & Genetics
Journal title
MOLECULAR GENETICS AND METABOLISM
ISSN journal
10967192 → ACNP
Volume
73
Issue
1
Year of publication
2001
Pages
111 - 113
Database
ISI
SICI code
1096-7192(200105)73:1<111:RSMCTL>2.0.ZU;2-8
Abstract
The DNA polymorphism SNP-43 in the calpain-10 gene is associated with insul in resistance and reduced skeletal muscle transcript in Pima Indians. Alter native splicing generates transcript isoforms calpain-10a to -10h. We deter mined the contribution of calpain-10 mRNA isoforms to the decreased total s keletal muscle calpain-10 mRNA levels observed in the G/G homozygotes. The expression levels of the major isoforms, calpain-10a and -10f, were positiv ely correlated with the total calpain-10 mRNA levels, indicating a cumulati ve effect. (C) 2001 Academic Press.