Long-term effects of pergolide in the treatment of restless legs syndrome

Authors
Stiasny, K Wetter, TC Winkelmann, J Brandenburg, U Penzel, T Rubin, M Hundemer, HP Oertel, WH Trenkwalder, C
Citation
K. Stiasny et al., Long-term effects of pergolide in the treatment of restless legs syndrome, NEUROLOGY, 56(10), 2001, pp. 1399-1402
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
56
Issue
10
Year of publication
2001
Pages
1399 - 1402
Database
ISI
SICI code
0028-3878(20010522)56:10<1399:LEOPIT>2.0.ZU;2-2
Abstract
An open follow-up of a controlled study in patients with restless legs synd rome (RLS) shows that the beneficial effect of pergolide on RLS symptoms pe rsists throughout at least 1 year. Twenty-two patients of 28 (78.6%) contin ued to take pergolide. Polysomnographic measurements showed a persistent im provement of PLM index, PLMS arousal index, total sleep time, and sleep eff iciency (p = 0.0001). Side effects, in particular nausea, were common but w ere well controlled by domperidone in most patients.