SUSCEPTIBILITY TO FOSFOMYCIN OF MULTIRESI STANT SEROTYPE O12 PSEUDOMONAS-AERUGINOSA - MULTICENTRIC STUDY

In a multicentric study including 214 strains of Pseudomonas aeruginos a, we observed that serotype O12 is more frequently sensitive to fosfo mycine than other serotypes strains (72 % vs 13,2 %, p<0,000 001). Tim e killing experiments demonstrated that combination of ceftazidime-fos fomycine and amikacine-fosfomycine have usually bactericidal and syner gistic activities and could be used for the treatment of multiresistan t Pa O12 infections, However, an antagonism between beta-lactams and f osfomycin in disk diffusion needs an adequate concentration of both an tibiotics in the site of infection.