Exposure to bisphenol A during the fetal and suckling periods disrupts sexual differentiation of the locus coeruleus and of behavior in the rat

This study rested the effect of exposure to bisphenol A (BPA) early in life on the sexual differentiation in the brain and behavior in Wister rats. We administered BPA only to mother rats during pregnancy and lactation at a d osage of approximately 1.5 mg/kg per day far less than the no-observed-adve rse-effect level (NOAEL; 50 mg/kg per day). Control female offspring showed a higher activity, a lower avoidance memory, and larger locus coeruleus th an the male controls, while the BPA-exposed group did not show any sexual d imorphism. BPA did not affect the reproductive organs or sex hormones. Our results suggest that the current methods to determine the NOAEL of artifici al industrial chemicals may not be sufficient to detect a disruption of the sexual differentiation in the brain. (C) 2001 Elsevier Science Ireland Ltd . All rights reserved.