Mitomycin C influence on inhibition of cellular proliferation and subsequent synthesis of type 1 collagen and laminin in primary and recurrent pterygia

The purpose was to investigate the biological effects of mitomycin C (MMC) on the inhibition of cellular proliferation and the subsequent synthesis of extracellular matrix like type I collagen (PIP) and laminin on primary and recurrent pterygia, The H-3-thymidine assay for cellular proliferation was consistent with the MMC dose and time response of both pterygia, The cellu lar inhibitory effect of MMC was greater on recurrent pterygial cells than primary ones. The inhibition of laminin by MMC followed the dose and time-r esponse curves, with a stronger effect found in recurrent pterygial cells, but no significant difference between the two types concerning type I colla gen synthesis. The inhibition of fibroblast proliferation and subsequent sy nthesis of laminin by MMC was more marked in recurrent pterygium than the p rimary one. Copyright (C) 2001 S. Karger AG, Basel.