A personal perspective on the study of experimental models of hydrocephalus
is offered. Many animal models a re available; each has its own advantages
and disadvantages. Detailed study of more than one model is needed to clar
ify the pathogenesis of hydrocephalus-induced brain damage in the immature
nervous system. Further information is needed about the mechanism of axonal
injury in periventricular tissue, changes in the extracellular compartment
, water dynamics within brain tissue, the role of neurotrophic factors in h
ydrocephalus, and the sites of injury in chronic 'arrested' hydrocephalus.
Insight into the multifactorial nature of the brain damage may allow us to
develop supplemental pharmacologic therapies, which could protect the brain
and promote recovery in the pre- and postshunt period.