A. Klockgetherradke et al., ONDANSETRON, DROPERIDOL AND THEIR COMBINATION FOR THE PREVENTION OF POSTOPERATIVE VOMITING IN CHILDREN, European journal of anaesthesiology, 14(4), 1997, pp. 362-367
In this study the antiemetic effects of droperidol, ondansetron and th
eir combination were evaluated in 160 ASA Grade I and II children unde
rgoing surgery for strabismus, who were randomly assigned to one of fo
ur groups: Group D received droperidol 75 mu g kg(-1), group O ondanse
tron 0.1 mg kg(-1), group D + O received both droperidol 75 mu g kg(-1
) and ondansetron 0.1 mg kg(-1), and group N NaCl as placebo. Emesis w
ithin the first 24 h occurred in 95.0% of the children with placebo me
dication, compared with 32.5% (D), 40.0% (O) and 45.0% (D+O) in the gr
oups with antiemetic prophylaxis. The differences between group N and
all other groups were significant (P<0.001). However, there were no st
atistically significant differences between the groups D, O and D + O.
It is concluded that droperidol (75 mu g kg(-1)) and ondansetron (0.1
mg kg(-1)) both significantly reduce PONV in children undergoing surg
ery for strabismus. Neither ondansetron, nor the combination D + O wer
e superior to droperidol alone.