Gf. Vafina et al., Synthesis and properties of 2,4-bis(ethoxycarbonyl)- and 2,4-diacetyl-3-hetaryl-5-hydroxy-5-methylcyclohexanones, RUSS J ORG, 36(12), 2000, pp. 1709-1716
Michael addition of ethyl acetoacetate and acetylacetone to heterocyclic al
dehydes gave, respectively, 2,4-bis(ethoxycarbonyl)- and 2,4-diacetyl-3-het
aryl-5-hydroxy-5-methylcyclohexanones as mixtures with the corresponding en
ols. Reaction of the addition products with hydrazines afforded 4,5-trans-2
-alkyl-5-ethoxycarbonyl(or acetyl)-4-hetaryl-6-hydroxy-6-methyl-4,5,6,6-tet
rahydro-2 H -indazoles with high stereo-selectivity.