M. Gold et al., A 66-YEAR-OLD WOMAN WITH A RAPIDLY PROGRESSING DEMENTIA AND BASAL GANGLIA INVOLVEMENT, Journal of neuroimaging, 7(3), 1997, pp. 171-175
Citations number
41
Categorie Soggetti
Clinical Neurology","Radiology,Nuclear Medicine & Medical Imaging
A 66-year-old woman presented with a rapidly progressive dementia init
ially characterized by an auditory agnosia. She experienced a rapid pr
ogression of her aphasia and developed ataxia and myoclonus. An initia
l neurological evaluation suggested a left parieto-temporal lesion, ho
wever, neuroimaging did not reveal any. An MRI of her brain demonstrat
ed highly focal T2 hyperintensities in her basal ganglia. The patient
was diagnosed with Creutzfeldt-Jacob Disease (CJD) on the basis of the
presence of two proteins in the CSF that are highly sensitive and spe
cific for CJD. Pathological examination confirmed the diagnosis. The d
ifferential diagnosis and utility of MRI in patients with CJD is discu
ssed.