The use of pesticides in Ghanaian agriculture, though beneficial in re
ducing crop loss both before and after harvest, has been associated wi
th threats to human health often due to the misapplication of the chem
icals. This study was an initial attempt to explore the knowledge, att
itudes and practices of 123 farm workers on three irrigation project a
reas in the Accra Plains, Ghana, regarding the safe handling and use o
f pesticides, to assess the prevalence of symptoms associated with org
anophosphorus pesticides (OPs) and carbamates and to determine the pre
valence of pesticide-related symptoms, and blood cholinesterase. The s
tudy design was cross-sectional in type. Methods used were interviews
and observation, and biological monitoring. The results revealed moder
ate levels of knowledge of the routes of absorption of pesticides and
of potential symptoms following exposure. Knowledge of personal protec
tive measures was poor to moderate. High risk practices included frequ
ent handling of the chemicals, home storage of pesticides and short re
-entry intervals. Despite knowledge of some health risks associated wi
th pesticides, the use of personal protective equipment (PPE) was mini
mal due primarily to financial constraints. The prevalence or symptoms
was higher and cholinesterase levels lower than in a control group of
teachers. It is suggested that there is a need for more epidemiologic
studies to investigate the problems associated with pesticide induced
ill health as well as research into appropriate and affordable PPE. P
PE needs to be subsidized. Training of agriculture and health workers
in safety precautions, recognition, and management of pesticide-relate
d ill health is a matter of urgency.