The field of interstellar molecules is reviewed with special considera
tion of recent observational and technical advances in the shorter sub
-millimeter wave region of the electromagnetic spectrum. At present mo
re than 110 interstellar molecules have been identified in interstella
r clouds and circumstellar envelopes. The more complex molecules are f
ound in the dense cores which are often the sites of active star forma
tion. These locations represent prime targets for the search of larger
molecules such as glycine. However, in the list of detected interstel
lar molecules many simple hydrides are still missing, including, e.g.,
SH, PH, PH2, etc., which constitute the building blocks of larger mol
ecules. With the technological opening of the terahertz region (nu con
gruent to 1 THz corresponds to lambda congruent to 0.3 mm) to both lab
oratory and interstellar spectroscopy, great scientific advances are t
o be expected. Amongst these will be the direct detection of the lowes
t rotational transitions of the light hydrides, the low energy bending
Vibrations of larger (linear) molecules, and possibly the ring-pucker
ing motion of larger ring molecules like the polycyclic (multiring) ar
omatic hydrocarbons. (C) 1997 Elsevier Science B.V.