DDT - a novel domain in different transcription and chromosome remodeling factors

Authors
Doerks, T Copley, R Bork, P
Citation
T. Doerks et al., DDT - a novel domain in different transcription and chromosome remodeling factors, TRENDS BIOC, 26(3), 2001, pp. 145-146
Citations number
20
Categorie Soggetti
Biochemistry & Biophysics
Journal title
TRENDS IN BIOCHEMICAL SCIENCES
ISSN journal
09680004 → ACNP
Volume
26
Issue
3
Year of publication
2001
Pages
145 - 146
Database
ISI
SICI code
0968-0004(200103)26:3<145:D-ANDI>2.0.ZU;2-N
Abstract
Homology-based sequence analyses have revealed the presence of a novel doma in (DDT) in bromodomain PHD finger transcription factors (BPTFs), chromatin remodeling factors of the BAZ-family and other putative nuclear proteins. This domain is characterized by a number of conserved aromatic and charged residues and is predicted to consist of three a helices. Recent studies ind icate a likely DNA-binding function for the DDT domain.