HMG1 and 2, and related 'architectural' DNA-binding proteins

Authors
Thomas, JO Travers, AA
Citation
Jo. Thomas et Aa. Travers, HMG1 and 2, and related 'architectural' DNA-binding proteins, TRENDS BIOC, 26(3), 2001, pp. 167-174
Citations number
66
Categorie Soggetti
Biochemistry & Biophysics
Journal title
TRENDS IN BIOCHEMICAL SCIENCES
ISSN journal
09680004 → ACNP
Volume
26
Issue
3
Year of publication
2001
Pages
167 - 174
Database
ISI
SICI code
0968-0004(200103)26:3<167:HA2AR'>2.0.ZU;2-S
Abstract
The HMG-box proteins, one of the three classes of high mobility group (HMG) chromosomal proteins*, bend DNA and bind preferentially to distorted DNA s tructures. The proteins appear to act primarily as architectural facilitato rs in the assembly of nucleoprotein complexes; for example, in effecting re combination and in the initiation of transcription. HMG-box proteins might be targeted to particular DNA sites in chromatin by either protein-protein interactions or recognition of specific DNA structures.