The complexities of dystroglycan

The notion of dystroglycan as a simple laminin-binding receptor is increasi ngly being challenged. New roles and new binding partners are continually e merging. Recent structural advances have provided exciting new insights int o the precise molecular interactions between dystroglycan and other key com ponents of the dystroglycan complex. Coupled with an increasing understandi ng of dystroglycan function at the molecular level, we are finally beginnin g to probe the complexities of dystroglycan, not only in disease, but in de velopment, adhesion and signalling.