Integrin-associated protein (CD47) and its ligands

Integrin-associated protein (IAP or CD47) is a receptor for thrombospondin family members, a ligand for the transmembrane signaling protein SIRP alpha and a component of a supramolecular complex containing specific integrins, heterotrimeric G proteins and cholesterol. Peptides containing a VVM motif in the C-terminal domain of thrombospondins are agonists for CD47, initiat ing heterotrimeric Gi protein signaling that augments the functions of inte grins of the beta1, beta2 and beta3 families, thus modulating a range of ce ll activities including platelet activation, cell motility and adhesion, an d leukocyte adhesion, migration and phagocytosis.