Chromosomal passengers and the (aurora) ABCs of mitosis

Authors
Adams, RR Carmena, M Earnshaw, WC
Citation
Rr. Adams et al., Chromosomal passengers and the (aurora) ABCs of mitosis, TR CELL BIO, 11(2), 2001, pp. 49-54
Citations number
35
Categorie Soggetti
Cell & Developmental Biology
Journal title
TRENDS IN CELL BIOLOGY
ISSN journal
09628924 → ACNP
Volume
11
Issue
2
Year of publication
2001
Pages
49 - 54
Database
ISI
SICI code
0962-8924(200102)11:2<49:CPAT(A>2.0.ZU;2-S
Abstract
Chromosomal passengers are proteins that move from centromeres to the spind le midzone during mitosis. Recent experiments show that the passengers inne r centromere protein (INCENP) and aurora-B kinase are in a macromolecular c omplex that might also contain a third passenger, survivin. The chromosomal passenger complex functions throughout mitosis in chromosome condensation and segregation, and at the end of mitosis, in the completion of cytokinesi s.