New insights into progressive supranuclear palsy

Increased oxidative damage and mitochondrial dysfunction have been suggeste d to play crucial roles in the pathogenesis of several neurodegenerative di seases, including Parkinson's disease and Alzheimer's disease. In this revi ew, we will focus on progressive supranuclear palsy (PSP), a rare parkinson ian disorder with tau pathology. Particular emphasis is placed on the genet ic and biochemical data that has emerged, offering new perspectives into th e pathogenesis of this devastating disease, especially the contributory rol es of oxidative damage and mitochondrial dysfunction.