The relation of the peak doppler E-wave to peak mitral annulus velocity ratio to diastolic function

Previous observations (Garcia et al, 1998; Sohn et al, 1997; Nagueh et al, 1997) indicate that mitral annulus velocity may be viewed as a "load-indepe ndent" index of filling and that wedge pressure is linearly related to the transmitral flow velocity (V-E) to mitral annulus velocity (V-MA) ratio (V- E/V-MA) measured at maximum velocity. In healthy subjects, the mean value o bserved for [V-E](max)/[V-MA](max) was 1:0.23 congruent to 4, No prior phys iologic or physical explanation for the basis of, or for the magnitude of, the ratio has been proposed. We propose a physiologic, model-based, quantit ative explanation for these observations and test our simplified model's pr ediction in an invasive (n = 30) and noninvasive (n = 34) test groups of su bjects. The simplified geometric model is based on the known constant volum e (within a few percentage points) attribute of the four-chambered heart. A ccordingly, left-atrial and left-ventricular volumes reciprocate so that th eir sum is constant throughout the cardiac cycle. The model predicts that: 1. the ratio (V-E/V-MA) is a constant congruent to3 in healthy hearts; and 2, V-E/V-MA should be linearly proportional to left ventricular end-diastol ic pressure (LVEDP), Model prediction was tested using V,and V-MA echocardi ographic data from 34 subjects (noninvasive group), and simultaneous echoca rdiographic and high-fidelity hemodynamic (LVEDP) data in 30 subjects (inva sive group). Excellent agreement was observed between model prediction and observed data. For the noninvasive (healthy) group, [V-E](max)/[V-MA](max) = 4.20 +/- 1,11, For the invasive group, [V-E](max)/[V-MA](max) was observe d to be linearly related to LVEDP, [V-E](max)/[V-MA](max) = 0.19 (LVEDP) 1.54, r = 0.92, Hence, [V-E](max)/[V-MA](max) is a legitimate flow-derived index of diastolic function because it is a derivable consequence of the he art's constant-volume pump attribute. (C) 2001 World Federation for Ultraso und in Medicine & Biology.