Dietary exposure to 3,3 ',4,4 ',5-pentachlorobiphenyl (PCB 126) or 2,3,7,8-tetrachlorodibenzo-P-dioxin (TCDD) does not induce proliferation of squamous epithelium or osteolysis in the jaws of weanling rats

Authors
Aulerich, RJ Yamini, B Bursian, SJ
Citation
Rj. Aulerich et al., Dietary exposure to 3,3 ',4,4 ',5-pentachlorobiphenyl (PCB 126) or 2,3,7,8-tetrachlorodibenzo-P-dioxin (TCDD) does not induce proliferation of squamous epithelium or osteolysis in the jaws of weanling rats, VET HUM TOX, 43(3), 2001, pp. 170-171
Citations number
10
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
VETERINARY AND HUMAN TOXICOLOGY
ISSN journal
01456296 → ACNP
Volume
43
Issue
3
Year of publication
2001
Pages
170 - 171
Database
ISI
SICI code
0145-6296(200106)43:3<170:DET3''>2.0.ZU;2-J
Abstract
Previous studies demonstrated that dietary exposure to 24 ppb 3,3'.4.4',5-p entachlorobiphenyl (PCB 126) or 2.4 ppb 2.3.7.8-tetrachlorodibenzo-p-dioxin (TCDD) induced maxillary and mandibular proliferation of periodontal squam ous epithelium, osteolysis of alveolar bone, and loose and displaced teeth in juvenile mi nk (Mustela vison). This study determined if such effects co uld be induced in laboratory rats. Feeding weanling male Long Evans rats 20 or 100 ppb PCB 126 or 1 or 10 ppb TCDD for up to 101 days caused a dose-de pendent decrease in body weight gains but did not produce the law lesion ob served in PCB 126 or TCDD-treated mink.