T. Hitschold et P. Berle, TRANSABDOMINAL CHORIONIC VILLI AND PLACEN TAL BIOPSY - RAPID CARYOTYPING THROUGHOUT THE ENTIRE PREGNANCY, Ultraschall in der Medizin, 18(3), 1997, pp. 134-138
Citations number
18
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging",Acoustics
Aim: The diagnostic value and the complication rate of transabdominal
chorionic villi and placental sampling was compared with standard amni
ocenteses. The method ist especially helpful In cases with conspicuous
fetal sonographic findings. Methods: The results of 475 biopsies were
retrospectively compared with 983 amniocenteses and chorionic villi s
amplings (CVS). Results: 64% of chorionic villi samplings (CVS) were p
erformed in the first, 30% in the second and 6% in the third trimester
. The indications were advanced maternal age (45%) and psychological p
roblems (14%) in the first trimester and conspicuous maternal serum ma
rkers (11%) or fetal ultrasound anomalies (12%) in the second and thir
d trimester, respectively. 10 out of 20 aneuploid cytogenetic results
were found in fetuses with sonographic anomalies. In 4 cases we found
confined placental mosaicism, which was clarified by means of amniocen
tesis and cordocentesis. We had 8 miscarriages in a total of 475 CVS p
rocedures; 6 in 304 before the 15th week of gestation (1.97%). The nat
ural abortion rate in this gestational age is about 1%, the CVS-relate
d abortion rate therefore is near 1%. Conclusion: Transabdominal CVS i
s a low risk method for rapid caryotyping during the entire pregnancy.