J. Lapins et al., No human leukocyte antigen-A, -B or -DR association in Swedish patients with hidradenitis suppurativa, ACT DER-VEN, 81(1), 2001, pp. 28-30
Hidradenitis suppurativa (HS) is a cicatrizing, inflammatory and recurrent
disease restricted to inverse skin, such as that of the axilla and groin of
younger adults. In a previous study, using serological tissue-typing techn
iques, no significant increases in the human leukocyte antigen (HLA)-A and
-B specificities were found in patients with HS, The aim of this study was
to determine the frequencies of HLA-A, -B and, for the first time, HLA-DR a
lleles, using genomic tissue-typing methods in patients with HS, Forty-two
unrelated Swedish patients with HS were included and compared with 250 cont
rols. According to clinical staging adopted from Hurley all of the patients
had stage II HS, i.e. recurrent abscesses with tract formation and cicatri
zation and single or multiple widely separated lesions. No association with
HLA-A, -B or -DRB1 alleles was found in patients with HS, Genetic factors
associated with the HLA class I or II regions do not appear to contribute s
ignificantly to the possible genetic susceptibility of HS.