Hydrogen peroxide decomposition in the oral cavity

Purpose: To determine the clearance of hydrogen peroxide from the oral cavi ty of infants (3-4 yrs of age), juveniles (7-12 yrs of age), adults (35-66 yrs of age), and adults with impaired salivary flow (34-71 yrs of age). Mat erials and Methods: In all subjects, the amount of H2O2 present in the oral cavity was assessed following a 1-min brushing period with an experimental dentifrice formulated with 3% hydrogen peroxide for up to 9 mins postbrush ing. In addition, the oral clearance of 3% hydrogen peroxide delivered in a n experimental dentifrice formulated with 5% baking soda was determined in a control population of adults and adult subjects with impaired salivary fl ow. Results: Most of the hydrogen peroxide decomposed during brushing, with less than 30% of the prebrushing dose of hydrogen peroxide remaining in th e oral cavity after 1 min of brushing. No differences between infants, juve niles, and adults were seen in levels of hydrogen peroxide recovered from t he oral cavity after tooth brushing. When a mixture of hydrogen peroxide an d baking soda was used for brushing, less than 5% of the hydrogen peroxide was recovered from the oral cavity after 1 min of brushing. In conclusion, clearance of hydrogen peroxide from the oral cavity was very rapid in child ren, adults, and adults with impaired salivary flow. Decomposition of hydro gen peroxide was enhanced approximately six-fold in adults by the presence of baking soda in the dentifrice. No substantial amount of hydrogen peroxid e survived beyond the brushing period, and very little material would be pr esent to interact with soft tissues in the oral cavity after expectorating any remaining dentifrice containing hydrogen peroxide.