Pseudomonas aeruginosa in vitro corneal isolate sensitivity to ofloxacin, ciprofloxacin, and trovafloxacin: A comparative study

PURPOSE: To compare sensitivity of Pseudomonas aeruginosa corneal isolates to ofloxacin, ciprofloxacin, and trovafloxacin, METHODS: Sensitivities of P, aeruginosa corneal isolates to each antibiotic from the periods 1985 to 1987 (n 32) and 1995 to 1999 (n = 85) were evalua ted in vitro with E tests (AB Biodisk; Remel, Lenexa, Kansas). RESULTS: Overall, the percent of P, aeruginosa corneal isolates sensitive i n vitro to ofloxacin (106/117, 90.6%) was significantly less than to ciprof loxacin (113/117, 96.6%, P = .016) and trovafloxacin (113/117, 96.6%, P = . 016), We observed trends of decreasing sensitivity to ciprofloxacin and tro vafloxacin, which were not statistically significant. Sensitivity to ofloxa cin remained unchanged; however, sensitivity to ofloxacin was always less t han sensitivity to ciprofloxacin and trovafloxacin, CONCLUSION: Although in vitro susceptibilities may not correlate with in vi vo efficacy, our data suggest that ciprofloxacin and trovafloxacin are supe rior to ofloxacin in the treatment of P, aeruginosa keratitis, (Am J Ophtha lmol 2001;131:795-796, (C) 2001 by Elsevier Science Inc, All rights reserve d.).