An unexpected selectivity of a propranolol-derived molecular imprint for tamoxifen

Authors
Martin, PD Wilson, TD Wilson, ID Jones, GR
Citation
Pd. Martin et al., An unexpected selectivity of a propranolol-derived molecular imprint for tamoxifen, ANALYST, 126(6), 2001, pp. 757-759
Citations number
10
Categorie Soggetti
Chemistry & Analysis","Spectroscopy /Instrumentation/Analytical Sciences
Journal title
ANALYST
ISSN journal
00032654 → ACNP
Volume
126
Issue
6
Year of publication
2001
Pages
757 - 759
Database
ISI
SICI code
0003-2654(2001)126:6<757:AUSOAP>2.0.ZU;2-K
Abstract
During the evaluation of molecular imprinted polymers (MIPs) prepared again st the drug tamoxifen a propranolol-derived MIP was used as a positive cont rol. Surprisingly the propranolol-derived MIP showed considerable selectivi ty towards tamoxifen, and was indeed much more selective than the MIP prepa red using tamoxifen as the imprint molecule. The consequences of this unexp ected, cross reactivity for the use of MIPs in analytical chemistry is disc ussed.