The gastrointestinal transit profile of C-14-labelled poly(acrylic acids):an in vivo study

Authors
Riley, RG Green, KL Smart, JD Tsibouklis, J Davis, JA Hampson, F Dettmar, PW Wilber, WR
Citation
Rg. Riley et al., The gastrointestinal transit profile of C-14-labelled poly(acrylic acids):an in vivo study, BIOMATERIAL, 22(13), 2001, pp. 1861-1867
Citations number
12
Categorie Soggetti
Multidisciplinary
Journal title
BIOMATERIALS
ISSN journal
01429612 → ACNP
Volume
22
Issue
13
Year of publication
2001
Pages
1861 - 1867
Database
ISI
SICI code
0142-9612(200107)22:13<1861:TGTPOC>2.0.ZU;2-U
Abstract
The gastrointestinal distribution profiles for three C-14-labelled poly(acr ylic acid)s of different average molecular weights and degrees of cross-lin king have been established using the rat model. Despite initial differences in transit times and retention characteristics, these structural features were found to be of little influence to the overall gastrointestinal transi t of the materials under consideration. No evidence for the systemic absorp tion of any of the polymers could be identified. (C) 2001 Elsevier Science Ltd. All rights reserved.