Glycosidase inhibitors of gem-diamine 1-N-iminosugars structures in media of enzyme assays

Authors
Kondo, K Adachi, H Shitara, E Kojima, F Nishimura, Y
Citation
K. Kondo et al., Glycosidase inhibitors of gem-diamine 1-N-iminosugars structures in media of enzyme assays, BIO MED CH, 9(5), 2001, pp. 1091-1095
Citations number
24
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
9
Issue
5
Year of publication
2001
Pages
1091 - 1095
Database
ISI
SICI code
0968-0896(200105)9:5<1091:GIOG1S>2.0.ZU;2-D
Abstract
The relationships between structures and inhibitory activities of glycosida se inhibitors of gem-diamine 1-N-iminosugars in media of enzyme assays have been investigated. It has been proved that gem-diamine 1-N-iminosugar smoo thly undergoes a structural change to a hydrated ketone or its derivative v ia a hemiaminal in the media (pH 5.0-6.3), and that the products generated in the media as well as the parent gem-diamine 1-N-iminosugars potently inh ibit glycosidases. (C) 2001 Elsevier Science Ltd. Al rights reserved.