Synthesis and cytotoxicity evaluation of novel indolylpyrimidines and indolylpyrazines as potential antitumor agents

Authors
Jiang, B Yang, CG Xiong, WN Wang, J
Citation
B. Jiang et al., Synthesis and cytotoxicity evaluation of novel indolylpyrimidines and indolylpyrazines as potential antitumor agents, BIO MED CH, 9(5), 2001, pp. 1149-1154
Citations number
20
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
9
Issue
5
Year of publication
2001
Pages
1149 - 1154
Database
ISI
SICI code
0968-0896(200105)9:5<1149:SACEON>2.0.ZU;2-4
Abstract
Novel indolylpyrimidines and indolylpyrazines have been synthesized as pote ntial antitumor agents. They were screened in a panel of 60 human tumor cel l lines in vitro. Compounds 7, 9, 10, 15, 21 exhibited efficiently cytotoxi c activities with GI(50) values in the low micromolar range against a varie ty of human cancer cell lines. 2,4-Bis(3'-indolyl)pyrimidine 8 displayed se lective cytotoxic activity against IGROV1 tumor cell line with the GI(50) v alue below 0.01 muM. (C) 2001 Elsevier Science Ltd. All rights reserved.