Diagnosis, pathology, staging, treatment, and outcome of epithelial ovarian neoplasia in patients age < 21 years

BACKGROUND. Epithelial ovarian neoplasms are rare in patients under the age of 21 years. This is a report of a series of such patients documenting the ir presentation, histologic type, stage of disease, treatment, and outcome. METHODS. Clinical findings, histology, stage, treatment, and outcomes of 19 patients with epithelial ovarian neoplasia are reported. AU histology was rereviewed. RESULTS. The median age at the time of diagnosis was 19.7 years (range, 14. 1-21.8 years), and the median follow-up was 5.6 years (range, 0.2-19.5 year s). The most common presenting symptom was dysmenorrhea (100%) followed by abdominal pain (68%), and the initial diagnosis usually was made ultrasonog raphically. There were nine (47%) serous tumors, 7 (37%) mucinous tumors, 2 (11%) small cell carcinomas, and 1 (5%) endometrioid carcinoma. Seventy-ni ne percent of tumors were unilateral, and 84% were low malignant potential or well differentiated tumors. Surgical treatment included unilateral salpi ngo-oophorectomy in 12 patients (63%), total abdominal hysterectomy and bil ateral salpingo-oophorectomy in 6 patients (32%), and ovarian cystectomy in 1 patient (5%). Fifteen patients (79%) had Stage I disease, and 4 patients (21%) had Stage III disease at the time of diagnosis. There were two death s in this series, and both occurred in patients with small cell anaplastic carcinoma. CONCLUSIONS, Epithelial ovarian neoplasias are rare in patients in this age group but must be included in the differential diagnosis of an ovarian mas s. Most patients present with Stage I tumors of low malignant potential. In these patients, good survival is achieved with unilateral salpingo-oophore ctomy and preservation of fertility. In contrast, small cell carcinomas are very aggressive, and patients with this variant require intensive therapy. Cancer 2001;91:2065-70. (C) 2001 American Cancer Society.