Differential expression of the subunits of the glucose-6-phosphatase system in the clear cell type of human renal cell carcinoma - no evidence for anoverexpression of protein kinase B

Authors
Schmoll, D Balabanov, S Schwarck, D Burchell, A Kleist, B Zimmermann, U Walther, R
Citation
D. Schmoll et al., Differential expression of the subunits of the glucose-6-phosphatase system in the clear cell type of human renal cell carcinoma - no evidence for anoverexpression of protein kinase B, CANCER LETT, 167(1), 2001, pp. 85-90
Citations number
17
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER LETTERS
ISSN journal
03043835 → ACNP
Volume
167
Issue
1
Year of publication
2001
Pages
85 - 90
Database
ISI
SICI code
0304-3835(20010610)167:1<85:DEOTSO>2.0.ZU;2-R
Abstract
The expression of two components of the glucose-6-phosphatase system, the c atalytic subunit (G6PaseC) and the glucose-6-phosphate transporter, was ana lyzed in the clear cell type of human renal cell carcinoma. The expression of G6PaseC was decreased in tumours compared with non-tumourous tissue of t he same patient. The expression of G6PaseT varied with no general trend bet ween tumours and control tissue. The expression of protein kinase B (PKB) w as unchanged in the tumours, suggesting that the down-regulation of G6PaseC in clear cells and the maintenance of the transformed phenotype are not pr edominantly caused by an overexpression of PKB. (C) 2001 Elsevier Science i reland Ltd. All rights reserved.