C. Pallaud et al., APOC3, CETP, fibrinogen, and MTHFR are genetic determinants of carotid intima-media thickness in healthy men (the Stanislas Cohort), CLIN GENET, 59(5), 2001, pp. 316-324
Citations number
61
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Molecular Biology & Genetics
The purpose of this study was to examine the relationship between carotid i
ntima-media thickness (CIMT) inter-individual variability and 16 polymorphi
sms of 11 genes associated with cardiovascular risk factors (genes among li
pid and homocysteine metabolisms, blood viscosity, platelet aggregation, le
ukocyte adhesion and renin-angiotensin system). CIMT was measured by high r
esolution B-mode ultrasonography in an healthy population of 77 men and 84
women, aged 35-54 years and selected from a French Cohort: the Stanislas Co
hort.
The polymorphisms studied were genotyped by a multilocus approach. Statisti
cal analyses were carried out by ANOVA, after adjustment of CIMT for age, b
ody mass index, and smoking, and by multiple regression analyses. No associ
ation was found with APOB Thr71Ile, APOC3 -482CT, -455T/C, GpIIIa PIA, AT1R
1166A/C, AGT Met235Thr, CBS Ile278Thr, SELE 98G/T, and SELE Ser128Arg, pol
ymorphisms neither in men nor in women. Although, in women we did not find
ally association for APOC3 3206T/G, 3175C/G, 1100C/T, CETP Ile405Val, MTHFR
677C/T and fibrinogen-455G/A polymorphisms; in men these polymorphisms wer
e associated with CIMT variability (p less than or equal to 0.01; p less th
an or equal to 0.05). The most interesting finding was that altogether thes
e genes in men were able to explain a considerable part, 20.6%, of CIMT var
iability. Therefore, our study gives a new opportunity to understand CIMT v
ariability.