Cytostatic 6-arylpurine nucleosides III. Synthesis and structure-activity relationship study in cytostatic activity of 6-aryl-, 6-hetaryl- and 6-benzylpurine ribonucleosides

Authors
Hocek, M Holy, A Votruba, I Dvorakova, H
Citation
M. Hocek et al., Cytostatic 6-arylpurine nucleosides III. Synthesis and structure-activity relationship study in cytostatic activity of 6-aryl-, 6-hetaryl- and 6-benzylpurine ribonucleosides, COLL CZECH, 66(3), 2001, pp. 483-499
Citations number
22
Categorie Soggetti
Chemistry
Journal title
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS
ISSN journal
00100765 → ACNP
Volume
66
Issue
3
Year of publication
2001
Pages
483 - 499
Database
ISI
SICI code
0010-0765(200103)66:3<483:C6NISA>2.0.ZU;2-J
Abstract
A series of fifteen 6-aryl-, 6-hetaryl- and 6-benzylpurine ribonucleosides has been prepared by Pd-catalyzed cross-coupling reactions of 6-chloro-9-(2 ,3,5-tri-O-acetyl-beta -D-ribofuranosyl)-purine with arylboronic acids, het arylzinc halides, hetarylstannanes or benzylzinc halides followed by deprot ection. Structure-activity relationship study revealed that besides 6-(4-su bstituted phenyl)purine nucleosides, also some 6-hetaryl- and 6-benzylpurin e ribonucleosides possess considerable cytostatic activity.