Synthesis and reactivity of 7-azaindoles (1H-pyrrolo[2,3-b]pyridine)

Authors
Merour, JY Joseph, B
Citation
Jy. Merour et B. Joseph, Synthesis and reactivity of 7-azaindoles (1H-pyrrolo[2,3-b]pyridine), CURR ORG CH, 5(5), 2001, pp. 471-506
Citations number
130
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
CURRENT ORGANIC CHEMISTRY
ISSN journal
13852728 → ACNP
Volume
5
Issue
5
Year of publication
2001
Pages
471 - 506
Database
ISI
SICI code
1385-2728(200105)5:5<471:SARO7(>2.0.ZU;2-X
Abstract
The results of research into the chemistry of 7-azaindole during the last t wenty years are presented. New synthetic methods for the 7-azaindole struct ures are developed including palladium-catalysed cross-coupling reactions. Reactivity of 3-formyl-, 3-halogeno- and 2-lithio-7-azaindole derivatives i s reported. Functionalisation of the pyridine ring via the N-oxide is also described. In the last part, biological activity of various 7-azaindole der ivatives is briefly indicated.